THE UNITED REPUBLIC OF TANZANIA MINISTRY OF HEALTH KIBONG'OTO INFECTIOUS DISEASES HOSPITAL

Research Publication

Implementing Innovative Approaches to Improve Health Care Delivery Systems for Integrating Communicable and Non-Communicable Diseases Using Tuberculosis and Diabetes as a Model in Tanzania

Mpagama S.G., Byashalira K.C., Chamba N.G., et al.

This paper presents an innovative health systems approach developed and implemented in Tanzania to integrate the management of communicable and non-communicable diseases (NCDs), specifically tuberculosis (TB) and diabetes mellitus (DM). Recognizing that TB and diabetes often co-exist and interact to worsen patient outcomes, the study sought to design and test models that make healthcare delivery more patient-centered, efficient, and sustainable

Published at Oct. 29, 2025, 10:52 a.m.

Deploying Metagenomics to Characterize Microbial Pathogens During Outbreak of Acute Febrile Illness Among Children in Tanzania

Authors: S.R. Mziray, G. Githinji, Z.R. de Laurent, P.M. Mbelele, K.S. Mohammed, B.D. Wadugu, B.S. Grundy, S.K. Heysell, S.G. Mpagama, J.O. Chilongola

This cross-sectional study in Tanzania (Korogwe District, 2018–2019) used metagenomic next-generation sequencing (mNGS) to characterize microbes and antimicrobial resistance (AMR) genes in children with acute febrile illness (AFI). Blood samples from 25 children (mean age 11.6 years) were analyzed. Five potential microbial causes of AFI were identified: Escherichia coli (n=19), Paraclostridium bifermentans (n=2), Pegivirus C (n=2), Shigella flexneri (n=1), and Pseudomonas fluorescens (n=1). E. coli was the most prevalent and harbored most of the 12 detected AMR genes (including mdtC, acrF, mdtF, emrB). mNGS proved valuable for pathogen and AMR profiling in outbreak settings.

Published at Aug. 26, 2025, 5:50 a.m.